DDX58 is significantly induced in virus-infected DCs two to three hours before IFNB1 is. We developed an agent based model (ABM) that simulates the important part of the IFNB1-DDX58 positive feedback loop in order to show that small early amount of IFNB1 mRNA present in a population of cells, hides the existence of a subset of early responder cells reacting strongly to the infection.
The simulation emulates a portion of a medium with both infected and uninfected DCs. The extracellular model is two dimensional, and the medium is represented by a square lattice, where each lattice square has the size of a single cell. Each cell is simulated as an independent agent, where the agents interface through the extracellular medium. The graphical display engine generates an animation by depicting the state of the simulated area at each simulation step.